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Chemical structure and dominant pharmacology of each enantiomer of tramadol and also the M1 metabolite. An enantiomer is Each individual of the pair of molecules which might be mirror pictures of each other.
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Desmetramadol is a patented composition that eliminates these metabolic liabilities by providing the active tramadol metabolite instantly with no require for metabolic activation.
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The lack of statistically sizeable analgesia while in the trial B feminine population dosed with either tramadol or desmetramadol was anticipated a priori, for the reason that Generally menstruating Ladies exhibit a variable and rising cold-induced soreness tolerance and threshold in excess of recurring stimulation.
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